Adrenergic Fight-or-Flight

Adrenergic Fight-or-Flight: S-NO Falls on PKA Targets.

β-Adrenergic–regulated phosphorylation of the skeletal muscle CaV1.1 channel in the fight-or-flight response

CaV1 channels initiate excitation–contraction coupling in skeletal and cardiacmuscle. During the fight-or-flight response, epinephrine released by the adrenal medulla and norepinephrine released from sympathetic nerves increasemuscle contractility by activation of the β-adrenergic receptor/cAMP-dependent protein kinase pathway and up-regulation of CaV1 channels in skeletal and cardiac muscle. A...

Does "fight or flight" need updating?

Fight or flight? – Flight increases immune gene expression but does not help to fight an infection

Flight represents a key trait in most insects, being energetically extremely demanding, yet often necessary for foraging and reproduction. Additionally, dispersal via flight is especially important for species living in fragmented landscapes. Even though, based on life-history theory, a negative relationship may be expected between flight and immunity, a number of previous studies have indicate...

The proximal tubule in cystinosis: fight or flight?

Although rare, nephropathic cystinosis is a devastating monogenic disorder leading to renal failure in the second decade of life. Fanconi syndrome, the initial renal manifestation of cystinosis in the young child, established the proximal tubule as a primary target of injury now recognized as the result of mutations in cystinosin (CTNS), the lysosomal cystine-proton cotransporter.1 A major chal...